Representative Publications:
 
 
L-Y Chen, WW Pan, M. Chen, J-D Li, W Liu, G Chen, S Huang, TJ Papadimos, and ZK Pan. Synergistic induction of inflammation by bacterial products LPS and fMLP: An importanat microbial pathogenic mechanism. J. Immunol. In Press, 2008.
 
 
Mahanivong C, Chen HM, Yee SW, Pan ZK, Dong Z, and Huang S. Protein kinase C-CARMA3 signaling axis links Ras to NF-kB for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells. Oncogene. 27(9):1273-1280, 2008.
 
 
He R, Shepard LW, Chen J, Pan Z.K., Ye RD. Serum amyloid A is an endogenous ligand that differentially induces IL-12 and IL-23. J Immunol. 177(6):4072-4079; 20066.
 
 
Papadimos TJ, Smith L, Mukherjee S, Popovic D, Chen LY, Pan Z.K. A lack of toll-like receptor 4 expression variability in the immediate preoperative period: a pilot study of elective surgical patients. Eur J Anaesthesiol. 23(10):892-3 2006.
 
 
Pirbhai M, Dong F, Zhong Y, Pan ZK, Zhong G. The secreted protease factor CPAF is responsible for degrading pro-apoptotic BH3-only proteins in Chlamydia trachomatis-infected cells. J Biol Chem. 281(42):31495-501. 2006.
 
 
Bian D, Mahanivong C, Yu J, Frisch SM, Pan ZK, Ye RD, Huang S. The G(12/13)-RhoA signaling pathway contributes to efficient lysophosphatidic acid-stimulated cell migration. Oncogene. 25:2234-2244, 2006.
 
 
Chen L-Y, Doerner A., Lehmann P.F., Huang S., Zhong G., and Pan Z. K. A Novel Protein Kinase C Is a Signaling Component Downstream of GTPase RhoA and Mediates Chemoattractant-induced NF-kB Activation in Human Blood Monocytes. J. Biol. Chem. 280:22497-22501, 2005.
 
 
Joko H., Lim, J.H., Chen, L-F., Xu, H., Trompouki, E., Pan, Z.K., Mosialos, G., Li, J. NF-kB is essential for induction of CYLD, the negative regulator of NF-kB: evidence for a novel inducible auto-regulatory feedback pathway. J. Biol. Chem. 279:36171-36174, 2004.
 
 
Chen, L-Y., Ptasznik, A., and Pan, Z.K. (2004) RhoA and Rac1 signals in fMLP-induced NF-kB activation in human blood monocytes. Biochem. Biophys. Res. Commun. 319:629-635.
 
 
Bian, D., Su, S., Mahanivong, C., Cheng, R.K., Han, Q., Pan, Z.K., Sun, P., and Huang, S. (2004) Lysophosphatidic acid stimulates ovarian cancer cell migration via a Ras-MEK kinase 1 pathway. Cancer Res., 64:4209-4217.
 
 
Chen, L-Y., Zuraw, B.L., Ye, R.D. and Pan, Z.K. (2004) A Rho exchange factor mediates fMet-Leu-Phe-induced NF-kB activation in human peripheral blood monocytes. J. Biol. Chem. 279:7208-7212.
 
 
Su, H., McClarty, G., Dong, F., Hatch, G., Pan, Z., and Zhong, G. (2004) Activation of Raf/MEK/ERK/cPLA2 signaling pathway is essential for chlamydial acquisition of host glycerophospholipids. J. Biol. Chem. 279:9409-9416.
 
 
Pan, Z. K. (2004) Toll-like receptors (TLRs) and TLR-mediated signaling: more questions than answers. Am. J. Physiol. 286:L918-920.
 
  Chen, L-Y., Zuraw, B.L., Zhao, M., Liu, F-T., Huang, S., and Pan, Z.K. (2003) Involvement of protein tyrosine kinase in Toll-like receptor 4 (TLR4)-mediated NF-kB activation in human peripheral blood monocytes. Am. J. Physiol., 284:L607-L613.
 
  Chen, L-Y., Zuraw, B.L., Liu, F-T., Huang S., and Pan, Z.K. (2002) IL-1 Receptor-associated kinase and GTPase RhoA signal molecules are required for bacterial lipopolysaccharide (LPS)-induced cytokine gene transcription. J. Immunol., 169:3934-3939.
 
  Ptasznik, A., Chinta, S., Costa, M.A., Kalota, A., Swider, C.R., Katz, B.A., Demir, G., Pan, Z.K., and Gewirtz, A.M. (2002) Crosstalk between BCR/ABL oncoprotein and CXCR4 signaling through a Src family kinase in human leukemia cells. J. Exp. Med., 196:667-678.
 
  Han, Q., Leng, J., Bian, D., Mahanivong, C., Carpenter K.A., Pan, Z.K., Han, J., and Huang S.  (2002) Rac1-MKK3-p38-MAPKAKPK2 pathway promotes urokinase plaminogen activator mRNA stability in invasive breast cancer cells. J. Biol. Chem., 277:48379-48385.
 
  Christiansen, S., Eddleston, J., Woessner, K., Chambers, S., Ye, R.D., Pan, Z.K., and Zuraw, B.L. (2002) Upregulation of functional B1 bradykinin receptors in allergic airway inflammation. J. Immunol., 169:2054-2060.
 
  Chen, S., Bacon, K.B., Garcia, G., Liao, R., Pan, Z.K., Sullivan, S.K., Nakano, H., Matsuzawa, A., Brinkmann, V., Feng, L. (2001) FTY720, a novel transplantation drug, modulates lymphocyte migratory responses to chemokines. Transplant. Proc., 33:3057-63.
 
  Chen, J., Bakersville, C., Han, Q., Pan, Z.K., and Huang, S. (2001) av integrin, p38 mitogen-activated protein kinase and urokinase plasminogen activator are functionally linked in invasive breast cancer cells. J. Biol. Chem., 276:47901-47905.
 
  Ratajczak, J., Majka, M., Kijowski, J., Baj, M., Pan, Z.K., Marquez, L.A., Janowska-Wieczorek, A., Ratajczak, M.Z. (2001) Biological significance of MAPK, AKT and JAK-STAT protein activation by various erythropoietic factors in normal human early erythroid cells. Br. J. Haematol., 115:195-204.
 
  Huang, S., Chen, L-Y., Zuraw, B.L., Ye, R.D., and Pan, Z.K. (2001) Chemoattractant-stimulated NF-kB activation is dependent on the low molecular weight GTPase RhoA. J. Biol. Chem., 276:40977-40981.
 
  Pan, Z.K., Chen, L.Y., Cochrane, C.G., Zuraw, B.L. (2000) fMet-Leu-Phe stimulates proinflammatory cytokine gene expression in Human Peripheral Blood Monocytes: the Role of Phosphatidylinositol 3-kinase. J. Immunol., 164:404-411.
 
  Huang, S., New, L., Pan, Z.K., Han, J., Nemerow, G.R. (2000) Urokinase Plasminogen Activator/Urokinase-specific surface receptor expression and matrix invasion by breast cancer cells requires constitutive p38a mitogen-activated protein kinase activity. J. Biol. Chem., 275:12266-12272.
 
  Majka, M., Janowska-Wieczorek, A., Ratajczak, J., Kowalska, M.A., Vilaire, G., Pan, Z.K., Honczarenko, M., Marquez, L.A., Poncz, M., Ratajczak, M.Z. (2000) Stromal-derived factor 1 and thrombopoietin regulate distinct aspects of human megakaryopoiesis. Blood, 96:4142-51.
 
  Hsu, D.K., Yang, R-Y., Pan, Z., Salomon, D.R., Fung-Leung, W-P., Liu, F.T. (2000) Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses. Am. J. Pathol., 156:1073-1083.
 
  Pan, Z.K., Christiansen, S., Ptasznik, A., Zuraw, B.L. (1999) Requirement of PI 3-kinase activity for bradykinin stimulation of NF-B activation in cultured human epithelial cells. J. Biol. Chem., 274:9918-9922.
 
  Pan, Z. K. (1998) Anaphylatoxin C5a and C3a Induce NF-B activation in Human Peripheral Blood Monocytes. Biochem. Biophys. Acta., 1443:90-98.
 
  Pan, Z.K., Ye, R.D., Christiansen, S.C., Jagels, M.K., Bokoch, G.M., Zuraw, B.L. (1998) Role of the Rho GTPase in bradykinin stimulated NF-B activation and interleukin-1 gene expression in cultured human epithelial cells. J. Immunol., 160:3038-3045.
 
  Browning, D.D., Pan, Z.K., Prossnitz, E.R., Ye, R.D. (1997) Cell type and developmental stage-specific activation of NF-B by fMet-Leu-Phe in myeloid cells. J. Biol. Chem., 272:7995-8001.
 
  Quehenberger, O., Pan, Z.K., Prossnitz, E.R., Cochrance, C.G., Ye, R.D. (1997) Identification of an N-formyl peptide receptor ligand binding domain by a gain-of-function approach. Biochem. Biophys. Res. Commun., 238(2):377-381.
 
  Roglic, A., Prossnitz, E.R., Pan, Z.K., Ye, R.D. (1996) cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure. Biochem. Biophys. Acta., 1305:39-43.