Faculty: Wenhao Chen, MD, PhD.

Summary: Dr. Chen is interested in identifying the molecular mechanisms that regulate activation, differentiation, apoptosis, and tolerance in T cells, the processes that lead to the development of novel therapeutic strategies for preventing T cell-mediated transplant rejection and autoimmune diseases. He is currently investigating: 1) the role of cytokine milieu in the generation of interleukin-17-producing T helper 17 (Th17) cells and regulatory T cells; 2) the role of Janus tyrosine kinases (Jaks) and signal transducers and activators of transcription (Stats) in regulating T cell function in transplant rejection and tolerance; 3) the induction of transplant tolerance by targeting alloreactive memory T cells.

Recirculating T lymphocytes, recognizing their specific antigens on the surface of antigen-presenting cells, exert most adaptive immune and autoimmune responses. My research is focused on identifying the molecular mechanisms that regulate activation, differentiation, apoptosis, and tolerance in T lymphocytes. My current project aims at identification of "unique cytokine milieu" required for the generation of memory T (antigen-experienced T cells that persist long-term) vs CD4+CD25+Foxp3+ regulatory T cells (maintaining self-tolerance and suppressing various immune responses). The results of these studies will lead us to the development of novel therapeutic strategies for preventing T cell-mediated transplant rejection, autoimmune diseases (e.g., type 1 diabetes), and other immune disorders.