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Representative
Publications: |
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Mruk,
Iwona and Blumenthal, R.M. (2009)
Tuning the relative affinities for activating and repressing operators
of a temporally regulated restriction-modification system. Nucleic
Acids Research, 37:983-98.
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Lintner,
R.E., Mishra, P.K., Srivastava, P., Martinez-Vaz, B.M., Khodursky,
A.B., and Blumenthal, R.B. (2008) Limited functional
conservation of a global regulator among related bacterial genera: Lrp
in Escherichia, Proteus and Vibrio. BMC Microbiology 2008, 8:60.
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Mruk,
Iwona, Blumenthal, R.M. (2008)
Real-time kinetics of restriction-modification gene expression after
entry into a new host
cell. Nucleic Acids Res. 36:2581-2593.
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Mruk,
Iwona, Preeti, Rajesh, Blumenthal, R.M. (2007)
Regulatory circuit based on autogenous activation-repression: roles of
C-boxes and spacer sequences in control of the PvuII restriction-modification
system. Nucleic Acids Res. 35:6935-6952.
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Paul,
L., Mishra, P.K., Blumenthal, R.M., and Matthews, R.G. (2007) Integration of regulatory signals through involvement of
multiple global regulators: control of the Escherichia coli gltBDF operon
by Lrp, IHF, Crp, and ArgR. BMC Microbiol. 7:2, 1471-2180.
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Knowle,
D., Lintner, R.E., Touma, Y.M., Blumenthal, R.M. (2005) Nature
of the promoter activated by C.PvuII, an unusual regulatory protein conserved
among restriction-modification systems. J. Bacteriol. 87:488-497.
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Schubert,
H.L., Blumenthal, R.M., and Cheng, X. (2003) Many paths to
methyltransfer: a chronicle of convergence. Trends Biochem. Sci. 28: 329-335.
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Roberts,
R.J., Belfort, M., Bestor, T., Bhagwat, A.S., Bickle, T.A., Bitinaite,
J., Blumenthal, R.M., et al. (47 authors total). (2003) A nomenclature
for restriction enzymes, DNA methyltransferases, homing endonucleases and
their genes. Nucleic Acids Res. 31:1805-1812.
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Tani,
T.H., Khodursky, A., Blumenthal, R.M., Brown, P.O., and Matthews, R.G. (2002) Adaptation to famine: a family of stationary-phase genes revealed
by microarray analysis. Proc. Natl. Acad. Sci. USA 99:13471-13476.
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Bujnicki,
J.M., Feder, M., Radlinska, M., Blumenthal, R.M. (2002) Structure
prediction and phylogenetic analysis of a functionally diverse family of
proteins homologous to the MT-A70 subunit of the human mRNA:m6A methyltransferase.
J. Molec. Evol. 55:431-444.
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Naderer,
M., Brust, J.R., Knowle, D., Blumenthal, R.M. (2002) Mobility
of a restriction-modification system revealed by its genetic contexts in
three hosts. J. Bacteriol., 184:2411-2419.
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Cheng,
X., Blumenthal, R.M. (2002) Cytosines do it, thymines do it, even
pseudouridines do it Ð base flipping by an enzyme that acts on RNA.
Structure, 10:127-129.
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Bujnicki,
J.M., Blumenthal, R.M. and Rychlewski, L. (2002) Sequence analysis
and structure prediction of 23S rRNA: m1G methyltransferases reveals a
conserved core augmented with a putative Zn-binding domain in the N-terminus
and family-specific elaborations in the C-terminus. J. Mol. Microbiol.
Biotechnol. 4:93-99.
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Paul, L., Blumenthal, R.M. and Matthews, R.G. (2001) Activation from
a distance: roles of Lrp and integration host factor in transcriptional
activation of gltBDF. J. Bacteriol. 183:3910-3918.
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Blumenthal,
R.M. and Cheng, X. (2001) A Taq attack displaces bases. Nature
Struct. Biol. 8:101-103.
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Rice,
M.R., and Blumenthal, R.M. (2000) Recognition of native DNA methylation
by the PvuII restriction endonuclease. Nucleic Acids Res. 28:3143-3150.
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Vijesurier,
R.M., Carlock, L., Blumenthal, R.M. and Dunbar, J.C. (2000)
Role and Mechanism of Action of C.PvuII, a Regulatory Protein Conserved
among Restriction-Modification Systems. J. Bact. 182:477-487.
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Rice,
M.R., Koons, M.D. and Blumenthal, R.M. (1999) Substrate
recognition by the PvuII endonuclease: binding and cleavage of CAG5mCTG
sites. Nucleic
Acids Res. 27:1032-1038.
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VanBogelen,
R.A., Greis, K.D., Blumenthal, R.M., Tani, T.M. and Matthews, R.G. (1999) Mapping regulatory networks in microbial cells. Trends Microbiol. 7:320-328.
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Bhagwat,
S.P., Rice, M.R., Matthews, R.G., and Blumenthal, R.M. (1997)
Use of an inducible regulatory protein to identify members of a regulon:
application to the regulon controlled by the leucine-responsive regulatory
protein (Lrp) in Escherichia coli. J of Bacteriology 179:6254-6263.
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Wiese
II, D.E., Ernsting, B.R., Blumenthal, R.M. and Matthews, R.G. (1997)
A nucleoprotein activation complex between the leucine-responsive regulatory
protein and DNA upstream of the gltBDF operon in Escherichia coli. J. Molec.
Biol. 270:152-168.
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Adams,
G.M. and Blumenthal, R.M. (1997) The PvuII DNA (cytosine-N4)-methyltransferase
comprises two trypsin-defined domains, each of which binds a molecule of
S-adenosyl-L-methionine. Biochemistry 36:8284-8292.
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Gong,
W., O'Gara, M., Blumenthal, R.M. and Cheng, X. (1997) Structure
of PvuII DNA-(cytosine N4) methyltransferase, an example of domain permutation
and protein fold assignment. Nucleic Acids Res. 25: 2702-2715 (cover article).
cover image - PDF article.
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Master,
S.S. and Blumenthal, R.M. (1997) A genetic and functional analysis
of the unusually large variable region in the M•.AAluI DNA-(cytosine
C5)-methyltransferase. Mol. Gen. Genet. 257:14-22.
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Edited Books:
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Cheng, X., Blumenthal, R.M., ed. S-adenosylmethionine-dependent methyltransferases:
Structures and functions. River Edge (NJ): World Scientific; 1999. http://books.google.com/books?id=oUCKHnsZuukC
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Book Chapters:
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Schubert, H.L., Blumenthal, R.M., and Cheng, X. (2005) Protein methyltransferases:
their distribution among the five structural classes of AdoMet-dependent
methyltransferases. In: The Enzymes, vol. 24, Protein Methylation (Clarke,
S.G., and F. Tamanoi, eds.). Amsterdam: Elsevier, 24: 3-28. 570 pp.
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Horton, J.R., Blumenthal, R.M., and Cheng, X. (2004) Restriction endonucleases:
structure of the conserved catalytic core and the role of metal ions in
DNA cleavage. In: Restriction Endonucleases (A. Pingoud, ed.). Berlin:
Springer-Verlag, 14: 361-392.
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Blumenthal,
R.M. and Cheng, X. (2002)
Restriction-modification systems. In: Modern Microbial Genetics, 2nd
edition (Yasbin R.E. and Streips U.N.,
eds.). New York: Wiley. ISBN 0-471-38665-0 657 pp.
http://www.amazon.com/gp/reader/0471386650/ref=sib_dp_srch_pop?v=search-inside&keywords=blumenthal&go.x=0&go.y=0&go=Go!#
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Fauman, E.B., Blumenthal, R.M., and Cheng, X. Structure and evolution
of AdoMet-dependent methyltransferases. In: Cheng, X., Blumenthal, R.M.,
ed. S-adenosylmethionine-dependent methyltransferases: Structures and functions.
River Edge (NJ): World Scientific, 1999. p. 1-38.
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