Representative Publications:
 
 
Lazarus JJ, Kay MA, McCarter AL, Wooten RM. (2008) Viable Borrelia burgdorferi enhances interleukin-10 production and suppresses activation of murine macrophages. Infect Immun. Mar;76(3):1153-62. Epub 2007 Dec 17.
 
 
Woodman, M.E., Cooley, A.E., Miller, J.C., Lazarus, J.J., Tucker, K., Bykowski, T., Botto, M., Hellwage, J., R.M. Wooten*, and Stevenson, B.* (2007) Borrelia burgdorferi binding of host complement regulator factor H is not required for efficient mammalian infection. Infect. Immun. 75:3131-3139.
*These labs contributed equally to this manuscript.
 
 
Lipski, S.L., Akimana, C., Timpe, J.M., Wooten, R.M., Lafontaine, E.R. (2007) The Moraxella catarrhalis autotransporter McaP is a conserved surface protein that mediates adherence to human epithelial cells through its N-terminal passenger domain. Infect. Immun. 75:314-324.
 
  Crandall, H., Dunn, D.M., Ma, Y., Wooten, R.M., Zachary, J.F., Weis, J.H., Weiss, R.B., Weiss, J.J. (2006) Gene expression profiling reveals unique pathways associated with differential severity of lyme arthritis. J. Immunol. 177:7930-7942.
 
 
Lazarus, J.J., Meadows, M.J., Lintner, R.E., Wooten, R.M. (2006) IL-10 Deficiency promotes increased Borrelia burgdorferi clearance predominantly through enhanced innate immune responses. J Immunol. 177: 7076-7085.
 
 
Melillo, A., Sledjeski, D.D., Lipski, S., Wooten, R.M., Basrur, V., Lafontaine, E.R. (2006) Identification of aFrancisella tularensis LVS outer membrane protein that confers adherence to A549 human lung cells. FEMS Microbiol. Lett. 263:102-108.
 
  Lawrenz, M.B., Wooten, R.M., and Norris, S.T. (2004) Effects of vLsE Complementation on the Infectivity of Borrelia burgdorferi Lacking the Linear Plasmid Ip28-1. Infect. Immun., 72:6577-6585.
 
  Lawrenz, M.B., Wooten, R.M., Zachary, J.F., Drouin, S.M., Weis, J.J., Wetsel, R.A., and Norris, S.J. (2003) Effect of Complement Component C3 Deficiency on Experimental Lyme Borreliosis in Mice. Infect. Immun., 71:4432-4440.
 
  Yoder A., Wang X., Ma Y., Philipp, M. T., Heilbrun, M., Weis, J. H., Kirschning, C. J., Wooten, R. M., and Weis, J. J. (2003) Tripalmitoyl-S-Glyceryl-Cysteine-Dependent OspA Vaccination of Toll-Like Receptor 2-Deficient Mice Results in Effective Protection from Borrelia burgdorferi Challenge. Infect. Immun., 71:3894-3900.
 
  Wooten, R. M., Ying, M. A., Yoder, R. A., Brown, J. P., Weis, J. H., Zachary, J. F., Kirschning, C. J., and Weis, J. J. (2002) Toll-like receptor 2 plays a pivotal role in host defense and inflammatory response to Borrelia burgdorferi. Vector Borne Zoonotic Dis, 2:275-278.
 
  Wooten, R.M., Ma, Y., Yoder, R. A., Brown, J. P., Weis, J. H., Zachary, J. F., Kirschning, C. J., and Weis, J. J. (2002) Toll-like receptor 2 is required for innate, but not acquired, host defense to Borrelia burgdorferi. J. Immunol., 168:348-355.
 
  Wooten, R. M. and Weis, J. J. (2001) Host-pathogen interactions promoting inflammatory Lyme arthritis: use of mouse models for dissection of disease processes. Curr. Opin. Micro., 4:274-279.
 
  Brown, E. L., Wooten, R. M., Johnson, B. J., Iozzo, R. V., Smith, A., Dolan, M.C., Guo, B. P., Weis, J. J., and Hook, M. (2001) Resistance to Lyme disease in decorin-deficient mice. J. Clin. Invest., 107:845-852.
 
  Brown, J. P., Zachary, J. F., Teuscher, C., Weis, J. J., and Wooten, R. M. (1999) Dual role of IL-10 in murine Lyme disease: Regulation of arthritis severity and host defense. Infect. Immun., 67:5142-5150.
 
  Hirschfeld, M., Kirschning, C. J., Schwandner, R., Wesche, H., Weis, J. H., Wooten, R. M., and Weis, J. J. (1999) Cutting Edge: Inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2. J. Immunol., 163:2382-2386.
 
  Wooten, R. M., Morrison, T. B., Weis, J. H., Wright, S. D., Thieringer, R., and Weis, J. J. (1998) The role of CD14 in signaling mediated by outer membrane lipoproteins of Borrelia burgdorferi. J. Immunol., 160:5485-5492.
 
  Wooten, R. M., Cutchens, M. A., Causey, A. L., Clem, L. W., and Bly, J. E. (1997) Effects of oleic acid on murine CD4+ T cell death and anti-CD3 or superantigen induced proliferation at low temperature. Dev. Comp. Immunol., 21:375-384.
 
  Wooten, R. M., Modur, V. R., McIntyre, T. M., and Weis, J. J. (1996) Borrelia burgdorferi outer membrane protein A (OspA) induces nuclear translocation of NF-kB and inflammatory activation in human endothelial cells. J. Immunol., 157:4584-4590.
 
  Causey, A. L., Wooten, R. M., Cuchen, M. A., Clem, L. W., and Bly, J. E. (1996) Anergy or cell death induced by low physiological temperature in mitogen-stimulated human T lymphocytes. J. Therm. Biology., 21:381-388.