Representative Publications:
 
  I.V. Kuzmin, I.S. Novella, R. Dietzgen, A. Padhi and C.E. Rupprecht. The Rhabdoviruses: Biodiversity, phylogenetics and evolution. Infection, Genetics and Evolution (in press).
 
  E. Domingo, C. Escarmís, L. Menendez-Arias, C. Perales, M. Herrera, I.S. Novella and J.J. Holland. Viral quasispecies dynamics: interactions and pathogenesis. In Origin and Evolution of Viruses. Second edition. E. Domingo, C. Parrish and J.J. Holland (eds.) (2008).
 
 
Novella, I.S, Dutta, R.N., Wilke, C.O. (2008) A linear relationship between fitness and the logarithm of the critical bottleneck size in vesicular stomatitis virus populations. Journal of Virology, Oct 1; 82: 12589-12590.
 
 
Ebendick-Corpus, B.E., Zarate, S., Presloid, J.B., and Novella, I.S. (2008) Antagonistic pleiotropy involving promoter sequences in a virus. J Mol Biol.
Oct; 382:342-352.
 
 
Dutta, R.N., Rouzine, I.M., Smith, S.D., Wilke, C.O. and Novella, I.S. (2008) Rapid adaptive amplification of preexisting variation in an RNA virus. J. Virol. May; 82:4354-4352.
 
 
Novella, I.S., Ebendick-Corpus, B.E., Zarate, S. and Miller, E.L. (2007) Emergence of mammalian-adapted vesicular stomatitis virus from persistent infections of insect-vector cells. J. Virol. Jun; 81:6664-6668.
 
 
Wilke, C.O., Forster, R. and Novella, I.S. (2006) Quasispecies in time-dependent environments. In Curr. Top. Microbiol. Immunol., E. Domingo (ed.), 299, pgs 33-50.
 
 
Novella, I.S., Gilbertson, D.L., Borrego, B., Domingo E., and Holland, J.J. (2005) Adaptability costs in immune escape variants of vesicular stomatitis virus. Virus Research, 107:27-34.
 
  Novella, I.S., Ball, L.A., and Wertz, G.W. (2004) Fitness analyses of vesicular stomatitis virus strains with rearranged genomes reveal replicative disadvantages. J. Virol., 78:9837-9841.
 
  Zárate, S. and Novella, I.S. (2004) Vesicular stomatitis virus evolution during alternation between persistent infection in insect cells and acute infection in mammalian cells is dominated by the persistence phase. J. Virol., 78:12236-12342.
 
 
Highlighted in Nature Reviews Microbiology (2004):
 
  I.S. Novella, L.A. Ball and G.W. Wertz. (2004) Fitness analyses of vesicular stomatitis virus strains with rearranged genomes reveal replicative disadvantages. J. Virol., 78:9837-9841.
 
  Novella, I.S., and Ebendick-Corpus, B.E. (2004) Molecular basis of fitness loss and fitness recovery in vesicular stomatitis virus. J. Mol. Biol., 342:1415-1421.
 
  Novella, I.S., Zárate, S., Ebendick-Corpus, B.E., Metzgar, D.  (2004) Positive selection of synonymous mutations in an RNA virus. J. Mol. Biol., 342:1423-1430.
 
  Novella, I.S., Reissig, D.D. and Wilke, C.O. (2004) Density-dependent selection in vesicular stomatitis virus. J. Virol., 78:5799-5804.
 
  Wilke, C.O., Reissig, D.D. and Novella, I.S. (2004) Replication at periodically changing multiplicity of infection promotes stable coexistence of competing viral populations. Evolution, 58:900-905.
 
  Novella, I.S. (2004) Negative effect of genetic bottlenecks on the adaptability of vesicular stomatitis virus. J. Mol. Biol., 336:61-67.